Haitham A Azeem*, Alaa Mohamed Hashim, Ashraf M. Alkabeer
Background: Glycated albumin (GA) and glycated hemoglobin (HbA1c) levels are affected not only by plasma glucose levels but also by albumin metabolism and hemoglobin metabolism, respectively. Our study is aiming to evaluate the role of (GA) as an indicator of the glycemic state and its correlation with HbA1c in hemodialysis patients with diabetes mellitus.
Research Design and Methods: Our study is a cohort prospective study done on 50 chronic uremic diabetic patients 23 males and 27 females at Al-Azhar Assuit University Hospital, from August 2016 to February 2017. All the studied patients were on regular HD 3 times/week, 4 hours session. Multiple regression analysis was done to assess the correlation between glycated albumin and HbA1c as indicators of glycemic state. Patients with pregnancy, nephrotic syndrome, neoplastic disorders, and anemia due to causes other than chronic renal disease as hemolytic anemia, chronic liver diseases, thyroid disorders, and those under immunosuppressive therapy were excluded.
Results: GA had had a highly significant predictor for PG (p-value = 0.001) VS HbA1c%, which was had a significant predictor (p-value = 0.021).
Conclusion: Our study suggested that while HbAlc is considered the gold standard test in estimating the glycemic state in diabetic patients, GA can be used as an indicator of the glycemic state in uremic patients on regular HD.