Andreas Wilson
Especially in the early stages of pancreatic tumors, surgery is the most crucial component of multimodal treatment ideas for oncological patients. While the impact of primary tumor excision on immune function has been examined in a number of studies, the effects of visceral surgery unrelated to a primary tumor on the organism that is carrying the tumor and on the primary tumor itself are still not entirely known. We coupled a mouse model of medically induced immune failure with an orthotopically implanted pancreatic cancer (SID). Over the course of 28 days, mortality and overall health, including body weight, were observed. MRI scans were used to monitor tumor growth on days 8 and days 27 after tumor implantation. The numbers of immune cells in the blood and spleen as well as the serum cytokines were measured on day 28. Compared to the control groups, SID causes a substantial worsening of the overall condition and a decreased increase in body weight in tumor-bearing mice. Mortality and tumor growth rate were unaffected. Following SID, tumor-bearing animals had more neutrophils and macrophages in their spleens. Additionally, peripheral blood levels of neutrophils and macrophages both increased. The data could help establish a fundamental knowledge of how the immune system and tumors interact as well as lead to fresh ideas for immunotherapeutic treatments.